Objective of the present review is to focus recent advancements in gastroretentive drug delivery system (GRDDS) technology and its implications in pharmaceutical formulation development. With upcoming new drug molecules, majority pose challenge in the field due to their lack of solubility and permeability. The way out is either to design new molecules or to opt for a novel approaches for such molecules. Design and development of GRDDS has emerged as a leading tool in the field of site specific drug delivery system. Gastro-retention is of potential benefit for drugs bearing poor solubility and display availability through absorption window. The main aim of present review is to discuss rationale for developing GRDDS and to discuss different advancements in technologies used for design and development of gastroretentive dosage forms.
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